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Effect of Nano-Gefitinib on Ehrlich carcinoma-mediated alteration in hepatic oxidative/antioxidant biomarkers and apoptotic markers in mice. ( A ) Malondialdehyde (MDA, nmol/g tissue). ( B ) Superoxide dismutase activity (SOD, U/mg protein). ( C ) Total glutathione (total GSH, nmol/mg protein). ( D ) Reduced glutathione (reduced GSH, nmol/mg protein). ( E ) Oxidized glutathione (GSSG, nmol/mg protein). ( F ) Serum alpha-fetoprotein (serum AFP). ( G ) BAX (BCL-2-associated X protein, ng/mg). ( H ) BCL2 (B-cell lymphoma 2, ng/mg). ( I ) BAX/BCL2 ratio. Statistical significance represented by ns = non-significant, * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001.

Journal: Pharmaceuticals

Article Title: Effect of Nano-Gefitinib on Solid Ehrlich Carcinoma via Targeting EGFR, RIPK2 Pathways, and Macrophage Reprogramming

doi: 10.3390/ph18111747

Figure Lengend Snippet: Effect of Nano-Gefitinib on Ehrlich carcinoma-mediated alteration in hepatic oxidative/antioxidant biomarkers and apoptotic markers in mice. ( A ) Malondialdehyde (MDA, nmol/g tissue). ( B ) Superoxide dismutase activity (SOD, U/mg protein). ( C ) Total glutathione (total GSH, nmol/mg protein). ( D ) Reduced glutathione (reduced GSH, nmol/mg protein). ( E ) Oxidized glutathione (GSSG, nmol/mg protein). ( F ) Serum alpha-fetoprotein (serum AFP). ( G ) BAX (BCL-2-associated X protein, ng/mg). ( H ) BCL2 (B-cell lymphoma 2, ng/mg). ( I ) BAX/BCL2 ratio. Statistical significance represented by ns = non-significant, * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001.

Article Snippet: Alpha-fetoprotein (AFP) was measured in serum using ELISA Kit specific for rat AFP from CUSABIO Co. (Wuhan, China; Cat. No. CSB-E08281r).

Techniques: Activity Assay